The Prognostic Value of Derivatives-Reactive Oxygen Metabolites (d-ROMs) for Cardiovascular Disease Events and Mortality: A Review.

Furthermore, after HFpEF patients were stratified according to the New York Heart Association (NYHA) [[89]] functional classes, d-ROM levels were found to be significantly higher in patients with NYHA III/IV than in those with NYHA II (median d-ROMs = 405 UCARR; IQR = 346-478 UCARR vs. median d-ROMs = 338 UCARR; IQR = 308-383 UCARR; I p i < 0.001). After matching the HFpEF and non-HF groups ( I n i = 212 each) for age, gender, and equal incidence of risk factors, d-ROM levels were found to be significantly higher in the HFpEF group than in the non-HF group (median d-ROMs = 343 UCARR; IQR = 312-394 UCARR vs. median d-ROMs = 336 UCARR; IQR = 288-381 UCARR; I p i < 0.001). Keywords: oxidative stress; blood biomarkers; d-ROMs; prognostic value; cardiovascular diseases; mortality EN oxidative stress blood biomarkers d-ROMs prognostic value cardiovascular diseases mortality N.PAG N.PAG 26 08/29/22 20220801 NES 220801 1. The d-ROM median value of 303 UCARR was used as the threshold to divide patients into a low-d-ROM group (group L; mean d-ROMs = 235 ± 45 UCARR) and a high-d-ROM group (group H; mean d-ROMs = 421 ± 85 UCARR). Below, we summarise the main results obtained in clinical studies that evaluated the correlations between d-ROM plasma levels and the risk of future CVD events and death in individuals affected by CVD (Table 1). 7.1. d-ROMs in Coronary Artery Disease (CAD) Masaki et al. [[77]] analysed the correlation between d-ROM values and the risk of future CVD events in a prospective cohort of 265 subjects with stable CVD, of whom 130 had known coronary artery disease CAD (defined as having at least one coronary stenosis proven by coronary angiography (CAG) or history of coronary revascularisation). [Extracted from the article]