PHYTOCHEMICAL SCREENING AND ANTIDYSLIPIDEMIC ACTIVITY OF CORIANDER LEAF ETHANOL EXTRACT (Coriandrum sativum L.) IN WISTAR MALE RATS.

Dyslipidemia is an important major issue that accounted for atherosclerosis and coronary heart disease. Therapy with synthetic drugs becomes a daily routine and can lead to multiple side effects. This makes herbal medicine often used as an additional treatment, one of which is coriander leaves (Coriandrum sativum L.). The goal of this research is to find out the lipid-lowering activity of coriander leaves ethanolic extract (CLEE) in male rats induced with the intake of a high-fat diet. The resulting data were analyzed by ANOVA (Analysis of Variance) then continued with the Post Hoc Tukey HSD test to see the differences between treatments. The result of this study shows that there were significant differences between the CLEE doses of 100, 200 and 400 mg/kg body weight. Based on the result show that CLEE has an effect in reducing levels of total cholesterol, LDL and triglycerides as well as increasing blood HDL levels of mice induced by a high-fat diet. Shown that of CLEE with affixed dose in 400 mg/kg BB has the best lipid-lowering agent among other treatments. [ABSTRACT FROM AUTHOR]