Back to Search
Start Over
Th2A cells: The pathogenic players in allergic diseases.
- Source :
- Frontiers in Immunology; 8/8/2022, Vol. 13, p01-10, 10p
- Publication Year :
- 2022
-
Abstract
- Proallergic type 2 helper T (Th2A) cells are a subset of memory Th2 cells confined to atopic individuals, and they include all the allergen-specific Th2 cells. Recently, many studies have shown that Th2A cells characterized by CD3<superscript>+</superscript> CD4<superscript>+</superscript> HPGDS<superscript>+</superscript> CRTH2<superscript>+</superscript> CD161<superscript>high</superscript> ST2<superscript>high</superscript> CD49d<superscript>high</superscript> CD27<superscript>low</superscript> play a crucial role in allergic diseases, such as atopic dermatitis (AD), food allergy (FA), allergic rhinitis (AR), asthma, and eosinophilic esophagitis (EoE). In this review, we summarize the discovery, biomarkers, and biological properties of Th2A cells to gain new insights into the pathogenesis of allergic diseases. [ABSTRACT FROM AUTHOR]
- Subjects :
- ALLERGIES
TH2 cells
ALLERGIC rhinitis
ATOPY
ATOPIC dermatitis
FOOD allergy
Subjects
Details
- Language :
- English
- ISSN :
- 16643224
- Volume :
- 13
- Database :
- Complementary Index
- Journal :
- Frontiers in Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 158658994
- Full Text :
- https://doi.org/10.3389/fimmu.2022.916778