Cutaneous gamma delta T‐Cell lymphoma with indolent evolution: a series of five cases.

Primary cutaneous T-cell lymphomas showing Gamma-Delta ( ) phenotype and predominantly Epidermotropic pattern are clinicopathologically distinct from classic primary cutaneous T-cell lymphomas. The last patient (n°4) experienced an ENT relapse (palate ulceration) after 42 months of remission under methotrexate. Cutaneous gamma delta T-cell lymphomas (CGDTCL) are rare lymphomas representing <1% of all cutaneous lymphomas, globally associated with a decreased overall survival.1,2 CGDTCL are a defined entity of the 2018 EORTC-WHO classification, most often presenting as nodules or infiltrated plaques, but mycosis fungoides-like3 and pagetoid reticulosis-like presentations have also been reported.4 The prognosis is generally poor.5,6 A few indolent cases have been reported.1,7-9 The clinical presentation of such indolent PCGDTCL has been poorly described. [Extracted from the article]