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NAPT, an unbiased approach for sequential analysis of the protein N- and C-terminome.
- Source :
- Journal of Materials Chemistry B; 8/28/2022, Vol. 10 Issue 32, p9397-9400, 4p
- Publication Year :
- 2022
-
Abstract
- Protein termini are generally associated with protein stability. Taking advantage of charge state differences between terminal peptides and internal peptides, we developed a new method termed LysargiNase-assisted Analysis of the Protein N- and C-Terminome (NAPT) for selective separation of protein termini. Altogether, we identified 2458 protein N-termini and 3056 protein C-termini from the HeLa cell line. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 2050750X
- Volume :
- 10
- Issue :
- 32
- Database :
- Complementary Index
- Journal :
- Journal of Materials Chemistry B
- Publication Type :
- Academic Journal
- Accession number :
- 158598347
- Full Text :
- https://doi.org/10.1039/d2cc03778e