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Evaluation of Non-infarct-Related Arteries Using C-11 Acetate PET in STEMI With Multivessel Disease.
- Source :
- Journal of Cardiovascular Imaging; Jul2022, Vol. 30 Issue 3, p169-180, 12p
- Publication Year :
- 2022
-
Abstract
- BACKGROUND: We analyzed whether C-11 acetate positron emission tomography (PET) can be used for the evaluation of non-infarct-related artery (NIRA) in patients with ST-elevation myocardial infarction (STEMI) and multivessel disease. METHODS: We prospectively enrolled 31 patients with STEMI and at least one NIRA stenosis (diameter stenosis [DS] ≥ 50%). C-11 acetate PET was performed after successful revascularization for the infarct-related artery (IRA). Myocardial blood flow (MBF) and oxidative metabolism (k<subscript>mono</subscript>) were measured and compared between NIRA vs. IRA, stenotic (DS ≥ 50%) vs. non-stenotic (DS < 50%) NIRAs, and NIRAs with significant stenosis (DS ≥ 70% or fractional flow reserve [FFR] ≥ 0.80) vs. those without (neither DS ≥ 70% nor FFR ≥ 0.80). The correlations between PET and angiographic parameters were also analyzed. RESULTS: MBF and kmono were significantly higher in NIRAs than those in IRAs. Stenotic NIRAs showed significantly reduced stress MBF, myocardial flow reserve (MFR), relative flow reserve (RFR) (0.72 ± 0.12 vs. 0.82 ± 0.14; p = 0.001), and stress kmono, as compared to those in non-stenotic NIRAs. NIRAs with significant stenosis had significantly lower stress MBF, MFR, and RFR (0.70 ± 0.10 vs. 0.80 ± 0.14; p = 0.001). RFR showed the best, but modest linear correlation with DS of NIRA stenosis (r = -0.429, p = 0.001). RFR > 0.81 could effectively exclude the presence of significant NIRA stenosis. CONCLUSIONS: C-11 acetate PET could be a feasible alternative noninvasive modality in patients with STEMI and multivessel disease, by excluding the presence of significant NIRA stenosis. [ABSTRACT FROM AUTHOR]
- Subjects :
- POSITRON emission tomography
ST elevation myocardial infarction
OXYGEN consumption
Subjects
Details
- Language :
- English
- ISSN :
- 25867210
- Volume :
- 30
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Journal of Cardiovascular Imaging
- Publication Type :
- Academic Journal
- Accession number :
- 158537112
- Full Text :
- https://doi.org/10.4250/jcvi.2021.0189