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FGFR3-TACCs3 Fusions and Their Clinical Relevance in Human Glioblastoma.
- Source :
- International Journal of Molecular Sciences; Aug2022, Vol. 23 Issue 15, p8675-8675, 16p
- Publication Year :
- 2022
-
Abstract
- Oncogenic fusion genes have emerged as successful targets in several malignancies, such as chronic myeloid leukemia and lung cancer. Fusion of the fibroblast growth receptor 3 and the transforming acidic coiled coil containing protein—FGFR3-TACC3 fusion—is prevalent in 3–4% of human glioblastoma. The fusion protein leads to the constitutively activated kinase signaling of FGFR3 and thereby promotes cell proliferation and tumor progression. The subgroup of FGFR3-TACC3 fusion-positive glioblastomas presents with recurrent clinical and histomolecular characteristics, defining a distinctive subtype of IDH-wildtype glioblastoma. This review aims to provide an overview of the available literature on FGFR3-TACC3 fusions in glioblastoma and possible implications for actual clinical practice. [ABSTRACT FROM AUTHOR]
- Subjects :
- CHRONIC myeloid leukemia
GLIOBLASTOMA multiforme
CHIMERIC proteins
GENE fusion
Subjects
Details
- Language :
- English
- ISSN :
- 16616596
- Volume :
- 23
- Issue :
- 15
- Database :
- Complementary Index
- Journal :
- International Journal of Molecular Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 158522056
- Full Text :
- https://doi.org/10.3390/ijms23158675