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Design strategy for an analyte-compensated fluorescent probe to reduce its toxicity.
- Source :
- Chemical Communications; 8/21/2022, Vol. 58 Issue 65, p9136-9139, 4p
- Publication Year :
- 2022
-
Abstract
- During biological detection, the toxicity caused by probes to living organisms is neglected. In this study, an analyte-compensated fluorescent probe (NP-SN<subscript>3</subscript>) was constructed for the detection of H<subscript>2</subscript>S. Through experiments with HepG2 cells and zebrafish embryos and larvae, the NP-SN<subscript>3</subscript> probe showed no significant difference in imaging performance compared with the traditional probe (NP-N<subscript>3</subscript>) but exhibited lower detection-induced toxicity in the imaging of liver fibrosis in activated HSC-T6 cells. During the development of zebrafish embryos and continuous administration in rats, NP-SN<subscript>3</subscript> showed a lower death rate, higher hatchability and lower malformation in zebrafish embryos and milder pathological symptoms in stained rat tissues. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 13597345
- Volume :
- 58
- Issue :
- 65
- Database :
- Complementary Index
- Journal :
- Chemical Communications
- Publication Type :
- Academic Journal
- Accession number :
- 158476921
- Full Text :
- https://doi.org/10.1039/d2cc02789e