Toward a more complete understanding of who will benefit from prehospital transfusion.

This occurred despite the fact that the patients in the prehospital transfusion group had a higher admission mean hemoglobin (Hb) concentration than the patients in the control arm (133 g/L vs. 118 g/L, respectively; I p i < 0.001), a small and nearly identical fraction of patients in both groups had an admission INR >1.5 (described above), and the patients in both groups had identical mean admission systolic blood pressures (114 mmHg; I p i = 0.74). It is clear from these three trials that some trauma patients derive lifesaving benefit from prehospital transfusions, and the design of future studies and sub-analyses should be further refined to more clearly elucidate those patients who might benefit. Keywords: COMBAT; emergency medical service; mortality; outcome; PAMPer; prehospital transfusion; randomized trial; red blood cell; RePHILL; trauma EN COMBAT emergency medical service mortality outcome PAMPer prehospital transfusion randomized trial red blood cell RePHILL trauma 1671 1679 9 08/09/22 20220801 NES 220801 Abbreviations BP blood pressure ED emergency department GCS Glasgow coma scale LTOWB low titer group O whole blood RBC red blood cell RCT randomized controlled trial For with much wisdom comes much sorrow, and as knowledge grows, grief increases. Similarly, recognizing patients with unsurvivable injuries (i.e., injuries leading to nonpreventable death) and excluding them from future studies will also help to better establish those patients who might benefit from prehospital transfusions.31-33 These should be major areas of future research to optimize patient care and to help steward the inventory of precious blood products. [Extracted from the article]