Back to Search
Start Over
Small biomarkers with massive impacts: PI3K/AKT/mTOR signalling and microRNA crosstalk regulate nasopharyngeal carcinoma.
- Source :
- Biomarker Research; 7/26/2022, Vol. 10 Issue 1, p1-12, 12p
- Publication Year :
- 2022
-
Abstract
- Nasopharyngeal carcinoma (NPC) is one of the most common malignant tumours of the head and neck in Southeast Asia and southern China. The Phosphatidylinositol 3-kinase/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signalling pathway is involved in processes related to tumour initiation/progression, such as proliferation, apoptosis, metastasis, and drug resistance, and is closely related to the clinicopathological features of NPC. In addition, key genes involved in the PI3K/AKT/mTOR signalling pathway undergo many changes in NPC. More interestingly, a growing body of evidence suggests an interaction between this signalling pathway and microRNAs (miRNAs), a class of small noncoding RNAs. Therefore, in this review, we discuss the interactions between key components of the PI3K/AKT/mTOR signalling pathway and various miRNAs and their importance in NPC pathology and explore potential diagnostic biomarkers and therapeutic targets. [ABSTRACT FROM AUTHOR]
- Subjects :
- NASOPHARYNX cancer
CELLULAR signal transduction
MICRORNA
NON-coding RNA
BIOMARKERS
Subjects
Details
- Language :
- English
- ISSN :
- 20507771
- Volume :
- 10
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Biomarker Research
- Publication Type :
- Academic Journal
- Accession number :
- 158383006
- Full Text :
- https://doi.org/10.1186/s40364-022-00397-x