Memantine targets glutamate receptors in atrial cardiomyocytes to prevent and treat atrial fibrillation.

The AF duration in the memantine group was also markedly shortened compared with that in the vehicle group (vehicle group versus memantine group: 157.8 ± 11.4 s versus 55.3 ± 17.4 s in the TAC-induced AF model, 226.5 ± 47.3 s versus 70.4 ± 9.8 s in the cholinergic AF model, and 173.6 ± 21.1 s versus 64.2 ± 11.7 s in the asphyxia-induced AF model). These authors contributed equally: Duanyang Xie, Ke Xiong, Xuling Su, Guanghua Wang, Luxin Wang Dear editor, Atrial fibrillation (AF), the most common sustained cardiac arrhythmia, can lead to severe consequences such as heart failure and stroke[1]. The AF duration in the memantine group was also markedly shortened compared with that in the vehicle group (vehicle group versus memantine group: 47.5 ± 12.6 s versus 0 s in the stretch-induced AF model, 86.8 ± 20.9 s versus 0 s in the cholinergic AF model, and 49.4 ± 15.3 s versus 0 s in the ischemia-induced AF model). [Extracted from the article]