An integrative pan‐cancer analysis of the molecular and biological features of glycosyltransferases.

Immune-related pathways, such as chemokine signaling pathway, cytokine-cytokine receptor interaction, leukocyte transendothelial migration, antigen processing and presentation, as well as PD-L1 expression and PD-1 checkpoint pathway, were associated with GTs in various cancer types gl The pan-cancer GT-pathway interaction (Figure 2E to G and Supporting information Table S6) and GT-protein interaction networks (Supporting information Figures S8 to S10 and Table S7) were constructed, respectively. Dear Editor, Glycosyltransferases (GTs) played important roles in cancer development and progression.1,2 Here, we conducted a pan-cancer analysis of GTs (Supporting information Table S1)3 based on the TCGA data, CCLE data, single-cell RNA sequencing datasets and our proteogenomic resource, aiming to characterize the molecular features, biological functions and clinical implications of GTs across cancer types. GTs with mutation frequency >5% are highlighted as asterisks, and a total of 41 GTs had more than 5.0% of mutation frequencies across the pan-cancer cohort. In addition to LUAD and SKCM, GTs correlating with the prognosis of patients in CD8 SP + sp T cell-enriched tumors were observed in other 26 types of cancers (Supporting information Table S8). [Extracted from the article]