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Atroposelective Construction of Nine‐Membered Carbonate‐Bridged Biaryls.
- Source :
- Angewandte Chemie International Edition; Aug2022, Vol. 61 Issue 31, p1-9, 9p
- Publication Year :
- 2022
-
Abstract
- We herein demonstrated an efficient method for the atroposelective construction of nine‐membered carbonate‐bridged biaryls through vinylidene ortho‐quinone methide (VQM) intermediates. Diverse products with desirable pharmacological features were synthesized in satisfying yields and good to excellent enantioselectivities. In subsequent bioassays, several agents showed considerable antiproliferative activity via the mitochondrial‐related apoptosis mechanism. Further transformations produced more structural diversity and may inspire new ideas for developing functional molecules. [ABSTRACT FROM AUTHOR]
- Subjects :
- BIOLOGICAL assay
QUINONE
APOPTOSIS
ORGANOCATALYSIS
MOLECULES
Subjects
Details
- Language :
- English
- ISSN :
- 14337851
- Volume :
- 61
- Issue :
- 31
- Database :
- Complementary Index
- Journal :
- Angewandte Chemie International Edition
- Publication Type :
- Academic Journal
- Accession number :
- 158165522
- Full Text :
- https://doi.org/10.1002/anie.202206501