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Development and In-Vitro Evaluation of Plantago ovata Based Rapid Disintegrating Tablets of Labetalol Hydrochloride.
- Source :
- Journal of Drug Delivery & Therapeutics; Jul/Aug2022, Vol. 12 Issue 4, p36-42, 7p
- Publication Year :
- 2022
-
Abstract
- Objectives: To avoid swallowing problems of conventional tablets and improved patient compliance Plantago Ovata based Labetalol HCl Rapid disintegrating tablets have been prepared. Methods: Six different (F1 to F6) batches of Labetalol HCl Rapid disintegrating tablets were developed by 'direct compression method' using Plantago ovata as a natural super-disintegrating agent. The formulated RDT were tested for angle of repose', densities like tapped and bulk density, Hausner's ratio, Carr's index like pre-compression parameters and for thickness, weight variation or weight uniformity, tablet hardness, % drug content or content uniformity, water absorption ratio', time require for wetting of tablets' means wetting time, in-vitro drug disintegration time and in-vitro drug dissolution studies under post-compression parameters of evaluation. Results: It was found that the all the results of these pre-compression and post-compression parameters comply with official standards. The drug release was determined using dissolution media of pH 6.8 phosphate buffer through in-vitro dissolution of drug. This study showed that a rapid drug release by prepared tablets. The optimized formulation F6 showed higher water absorption ratio, lower wetting time, minimum in-vitro disintegration time' and higher drug release amongst all the formulations. The F6 formulation was considered the best among all formulations. Conclusion: The prepared rapid disintegrating tablets shows rapid onset of action by quick drug release, minimize side effects and enhanced patient compliance. These prepared tablets containing selective alpha-1 and non-selective beta adrenergic antagonist' drug candidate Labetalol HCl, will be very useful in the treatment of high blood pressure with enhanced bioavailability. [ABSTRACT FROM AUTHOR]
- Subjects :
- ADRENERGIC beta blockers
DRUG solubility
LABETALOL
PLANTAGO
HYPERTENSION
Subjects
Details
- Language :
- English
- ISSN :
- 22501177
- Volume :
- 12
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Journal of Drug Delivery & Therapeutics
- Publication Type :
- Academic Journal
- Accession number :
- 158134776
- Full Text :
- https://doi.org/10.22270/jddt.v12i4.5430