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Risk of polymyxin B-induced acute kidney injury with a non adjusted dose versus adjusted dose based on renal function.
- Source :
- Personalized Medicine (17410541); Jul2022, Vol. 19 Issue 4, p307-314, 8p
- Publication Year :
- 2022
-
Abstract
- Aim: To observe the difference in the risk of polymyxin B (PMB)-induced acute kidney injury (AKI) with or without dose adjustment based on the patients renal function. Materials & methods: This retrospective cohort analysis was carried out in 115 patients treated with PMB from November 2018 to October 2019. Results: No significant difference in the incidence of AKI as well as secondary outcomes was observed between these two groups (47.5 vs 37.14%; p = 0.304). Conclusion: Dosing adjustment based on renal function does not significantly lower the risk of PMB-induced AKI. A non adjusted dosing strategy for PMB is recommended in patients exhibiting various levels of renal impairment. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 17410541
- Volume :
- 19
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Personalized Medicine (17410541)
- Publication Type :
- Academic Journal
- Accession number :
- 158113040
- Full Text :
- https://doi.org/10.2217/pme-2021-0003