Multiple Sclerosis: Cells Secreting Antibodies Against Myelin-Associated Glycoprotein are Present in Cerebrospinal Fluid.

We evaluated the B-cell response in cerebrospinal fluid (CSF) and blood by enumerating cells secreting antibodies to myelin-associated glycoprotein (MAG) and, for reference, to myelin basic protein (MBP), two myelin components which may constitute targets for autoimmune attack in multiple sclerosis (MS). Among 25 untreated MS patients, 12 had cells in CSF secreting anti- MAO IgG antibodies (mean value 1 per 1429 CSF cells) and three also had cells secreting anti- MAO antibodies of the IgM isotype but at lower levels. In CSF from 2 out of 10 MS patients examined, anti-MAO and anti-MBP IgO antibody-secreting cells were present concurrently. Antibody-secreting cells were less frequent in blood and bone marrow, reflecting compartmentalization to CSF. Anti-MAG antibody-secreting cells were found in CSF from only 1 out of 27 control patients. The intrathecal production of anti-MAG and anti-MBP antibodies may be important in the pathogenesis of MS. [ABSTRACT FROM AUTHOR]