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What Determines an Antigen-Specific IgE Isotypic Response?--A Hypothesis.
- Source :
- Scandinavian Journal of Immunology; Nov1991, Vol. 34 Issue 5, p519-529, 11p
- Publication Year :
- 1991
-
Abstract
- Two models to account for an antigen-specific IgE isotypic response are proposed. Both models assume a first-tiered IgE production induced by antigen and IL-4; however, the processed IgE or Ag-IgE immune complexes stimulate T∊ cells differently in the two models. In Model I, we propose that T∊ cells express conventional T-cell receptors which recognize IgE isolypic determinants. Model IA proposes that IgE fragments are processed and recognized along with class II MHC molecules, and T∊ cell preferentially act on antigen-activated IgE-committed B∊ cells via recognition of processed membrane IgE determinants but not antigens; thus T∊ cells are in principle capable of modulating non-antigenspecitic polyclonal IgE responses. Model IB proposes that IgE function as a class-restriction determinant for nominal antigens analogous to that of class II molecules, and T∊ cells exert stringent antigen-specific IgE isotypic responses by recognizing nominal antigens restricted to IgE, T∊ cells thus exert antigenspecific and IgE concerted immunoregulation, and do not participate in modulating polyclonal IgE production. Model II proposes a heterotypic interaction of IgE with a cell interaction receptor (or IgE Fc receptor) on T cells, T∊ cells modulate antigen-specific IgE isotypic responses via ligation with IgE-antigen immune complexes on B-cell surface; thus. T∊ cells in principle contribute to polyclonal IgH responses. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 03009475
- Volume :
- 34
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- Scandinavian Journal of Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 15797251
- Full Text :
- https://doi.org/10.1111/j.1365-3083.1991.tb01575.x