Variant t(11;22)(q13;q11.2) with IGL involvement in mantle cell lymphoma.

These patients presented with common characteristics of MCL, with PB involvement and lymphocytosis (2/3) and BM infiltration (2/3), and their clinical course was heterogeneous, indolent in three cases and aggressive, as in our patient, in the other two. Mantle cell lymphoma (MCL) is a mature B-cell neoplasm accounting for 5-10% of all non-Hodgkin lymphomas [[1]]. On the other hand, four cases of lymphoma with the t(2;11)(p11;q13) have been previously reported: three of them were classified as leukemic small-cell B-non-Hodgkin lymphoma [[7]], and the other one described as MCL [[14]]. In conclusion, the variant t(11;22)(q13;q11.2) in MCL is very uncommon and it is not associated with differentiated clinical features in MCL, but rather presents with the clinical characteristics of a MCL. [Extracted from the article]