Redistribution of CD8+ T cell subsets in metastatic renal cell carcinoma patients treated with anti‐PD‐1 therapy.

Renal‐cell carcinoma (RCC) is responsible for the majority of tumors arising from the kidney parenchyma. Although a progressive improvement in median overall survival has been observed after the introduction of anti‐PD‐1 therapy, many patients do not benefit from this treatment. Therefore, we have investigated T cell dynamics to find immune modification induced by anti‐PD‐1 therapy. Here, we show that, after therapy, RCC patients (5 responders and 14 nonresponders) are characterized by a redistribution of different subsets across the memory T cell compartment. [ABSTRACT FROM AUTHOR]