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LncRNA-Dependent Mechanisms of Transforming Growth Factor-β: From Tissue Fibrosis to Cancer Progression.
- Source :
- Non-Coding RNA; Jun2022, Vol. 8 Issue 3, p36-N.PAG, 23p
- Publication Year :
- 2022
-
Abstract
- Transforming growth factor-β (TGF-β) is a crucial pathogenic mediator of inflammatory diseases. In tissue fibrosis, TGF-β regulates the pathogenic activity of infiltrated immunocytes and promotes extracellular matrix production via de novo myofibroblast generation and kidney cell activation. In cancer, TGF-β promotes cancer invasion and metastasis by enhancing the stemness and epithelial mesenchymal transition of cancer cells. However, TGF-β is highly pleiotropic in both tissue fibrosis and cancers, and thus, direct targeting of TGF-β may also block its protective anti-inflammatory and tumor-suppressive effects, resulting in undesirable outcomes. Increasing evidence suggests the involvement of long non-coding RNAs (lncRNAs) in TGF-β-driven tissue fibrosis and cancer progression with a high cell-type and disease specificity, serving as an ideal target for therapeutic development. In this review, the mechanism and translational potential of TGF-β-associated lncRNAs in tissue fibrosis and cancer will be discussed. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 2311553X
- Volume :
- 8
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Non-Coding RNA
- Publication Type :
- Academic Journal
- Accession number :
- 157795874
- Full Text :
- https://doi.org/10.3390/ncrna8030036