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Kynurenine Metabolism as a Mechanism to Improve Fatigue and Physical Function in Postmenopausal Breast Cancer Survivors Following Resistance Training.
- Source :
- Journal of Functional Morphology & Kinesiology; Jun2022, Vol. 7 Issue 2, p45, 11p
- Publication Year :
- 2022
-
Abstract
- This pilot examines whether resistance training (RT) can induce changes in kynurenine (KYN) metabolism, which may contribute to improved physical function in breast cancer survivors (BCSs). Thirty-six BCSs (63.2 ± 1.1 years) underwent assessments of physical function and visual analog scale (100 cm) fatigue and quality of life before and after 12 weeks of RT (N = 22) or non-exercise control (CBCT©: Cognitively Based Compassion Training, N = 10). Blood was collected before and after interventions for assessment of KYN, kynurenic acid (KYNA), and peroxisome proliferator-activated receptor γ co-activator 1α (PGC-1α). At baseline, the women were moderately fatigued (mean score: 46 cm) and at risk of poor functional mobility. A group*time interaction was observed for all measures of strength with improvements (~25–35%) following RT (p's < 0.01), but not CBCT. Time effects were observed for fatigue (−36%) and quality of life (5%) (p's < 0.01), where both groups improved in a similar manner. A group*time interaction was observed for KYN (p = 0.02) and PGC-1α (p < 0.05), with KYN decreasing and PGC-1α increasing following RT and the opposite following CBCT. These changes resulted in KYN/KYNA decreasing 34% post-RT, but increasing 21% following CBCT. These data support RT as a therapeutic intervention to counteract the long-term side effect of fatigue and physical dysfunction in BCSs. Additionally, the results suggest that this effect may be mediated through the activation of PGC-1α leading to alterations in KYN metabolism. [ABSTRACT FROM AUTHOR]
- Subjects :
- PHYSICAL mobility
RESISTANCE training
CANCER survivors
KYNURENINE
BREAST cancer
Subjects
Details
- Language :
- English
- ISSN :
- 24115142
- Volume :
- 7
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Journal of Functional Morphology & Kinesiology
- Publication Type :
- Academic Journal
- Accession number :
- 157765029
- Full Text :
- https://doi.org/10.3390/jfmk7020045