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Effect of endoscopic radiofrequency ablation on the survival of patients with inoperable malignant biliary strictures: A large cohort study.
- Source :
- Journal of Hepato -- Biliary -- Pancreatic Sciences; Jun2022, Vol. 29 Issue 6, p693-702, 10p
- Publication Year :
- 2022
-
Abstract
- Background and Aims: Endoscopic radiofrequency ablation (RFA) is an emerging technique for the palliation of inoperable malignant biliary strictures (MBSs). We aimed to systemically investigate the long‐term outcome of RFA in a large cohort of patients. Methods: We recruited 883 patients with various MBSs who underwent endoscopic interventions at two large‐volume centers; 124 patients underwent RFA and stenting, whereas 759 underwent stenting alone. To overcome selection bias, we performed 1:4 propensity score matching (PSM). The main outcome was overall survival (OS). Results: Following PSM, patients in the RFA group showed significantly longer OS (9.5 months; 95% CI: 7.7‐11.3 months) than those in the stenting alone group (6.1 months; 95% CI: 5.6‐6.6 months; P <.001). In stratified analyses, the improved OS was only demonstrated in the subgroup of extrahepatic cholangiocarcinoma (11.3 months 95% CI: 10.2‐12.4 vs 6.9 months 95% CI: 6.0‐7.8; P <.001), but not in the subgroups of gallbladder cancer, hepatocellular carcinoma, intrahepatic cholangiocarcinoma, pancreatic cancer, and other metastatic cancers (all P >.05). The survival benefits were noted only in the patients with non‐metastatic cholangiocarcinoma (11.5 vs 7.4 months, P <.001). Conclusions: The survival benefits of endoscopic RFA appear to be limited to patients with extrahepatic cholangiocarcinoma without distant metastasis. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 18686974
- Volume :
- 29
- Issue :
- 6
- Database :
- Complementary Index
- Journal :
- Journal of Hepato -- Biliary -- Pancreatic Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 157710010
- Full Text :
- https://doi.org/10.1002/jhbp.960