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Antibacterial secondary metabolites from Vernonia auriculifera Hiern (Asteraceae) against MDR phenotypes.

Authors :
Jepkoech, Clara
Omosa, Leonidah Kerubo
Nchiozem-Ngnitedem, Vaderament-A.
Kenanda, Evans O.
Guefack, Michel-Gael F.
Mbaveng, Armelle T.
Kuete, Victor
Heydenreich, Matthias
Source :
Natural Product Research; Jun2022, Vol. 36 Issue 12, p3203-3206, 4p
Publication Year :
2022

Abstract

Purification of the aerial parts of Vernonia auriculifera Hiern afforded steroids (1–2), flavonoids (3–5), and polyalcohol (6). Their structures were determined using spectral evidences as well as by comparison with reported data. Iodonitrotetrazolium chloride (INT) colorimetric assay was used to assess the antibacterial activity of the extract and isolates against 13 pathogenic strains. The crude extract showed strong antibacterial activity (MIC < 100 µg/mL) against the tested bacterial strains. When combined with an efflux pump inhibitor phenylalanine beta naphthylamide (PAβN), the inhibition potency of the extract was substantially enhanced with the lowest MIC value at 4 µg/mL. Compounds 5 and 6 showed moderate activity (MIC < 100 µg/mL) against 12/13 (92.3%), and 8/13 (61.5%) bacterial strains, respectively. A minimal bactericidal concentration (MBC)/minimal inhibitory concentration (MIC) ratio ≤ 4 indicated their bactericidal effect against Escherichia coli, Enterbacter aerogenes, Klebsiella pneumoniae, Providencia stuartii, Pseudomonas aeruginosa, and Staphylococcus aureus. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
14786419
Volume :
36
Issue :
12
Database :
Complementary Index
Journal :
Natural Product Research
Publication Type :
Academic Journal
Accession number :
157611279
Full Text :
https://doi.org/10.1080/14786419.2021.1953024