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Pleural mesothelioma risk by industry and occupation: results from the Multicentre Italian Study on the Etiology of Mesothelioma (MISEM).

Authors :
Migliore, Enrica
Consonni, Dario
Peters, Susan
Vermeulen, Roel C. H.
Kromhout, Hans
Baldassarre, Antonio
Cavone, Domenica
Chellini, Elisabetta
Magnani, Corrado
Mensi, Carolina
Merler, Enzo
Musti, Marina
Marinaccio, Alessandro
Mirabelli, Dario
Source :
Environmental Health: A Global Access Science Source; 6/18/2022, Vol. 21 Issue 1, p1-13, 13p
Publication Year :
2022

Abstract

<bold>Background: </bold>The Italian mesothelioma registry (ReNaM) estimates mesothelioma incidence and addresses its etiology by assessing cases' exposures but cannot provide relative risk estimates.<bold>Objectives: </bold>i) To estimate pleural mesothelioma relative risk by industry and occupation and by ReNaM categories of asbestos exposure; and ii) to provide quantitative estimates of the exposure-response relationship.<bold>Methods: </bold>A population-based mesothelioma case-control study was conducted in 2012-2014 in five Italian regions. Cases and age and gender frequency-matched controls were interviewed using a standard ReNaM questionnaire. Experts coded work histories according to international standard classifications of industries/occupations and assigned asbestos exposure according to ReNaM categories. Job codes were further linked to SYN-JEM, a quantitative job-exposure matrix. Cumulative exposure (CE, f/mL-years) was computed by summing individual exposures over lifetime work history. Unconditional logistic regression analyses adjusted by gender, centre and age were fitted to calculate odds ratios (OR) and 95% confidence intervals (CI).<bold>Results: </bold>Among men we observed increased risks of mesothelioma in many industries and associated occupations, including: asbestos-cement (OR = 3.43), manufacture of railroad equipment (OR = 8.07), shipbuilding and repairing (OR = 2.34), iron and steel mills (OR = 2.15), and construction (OR = 1.94). ORs by ReNaM exposure categories were as follows: definite/probable occupational exposure (OR = 15.8, men; OR = 8.80, women), possible occupational (OR = 2.82, men; OR = 3.70, women), sharing home with an exposed worker (OR = 2.55, men; OR = 10.3, women), residential (OR = 2.14, men; OR = 3.24, women). Based on SYN-JEM, mesothelioma risk increased by almost 30% per f/mL-year (OR = 1.28, CI 1.16-1.42).<bold>Conclusions: </bold>Out study involved five regions with historically different types and levels of industrial development, encompassing one third of the Italian population and half of Italian mesothelioma cases. As expected, we found increased pleural mesothelioma risk in the asbestos industry and in trades with large consumption of asbestos materials. Clear associations were found using both qualitative (ReNaM classifications) and quantitative estimates (using SYN-JEM) of past asbestos exposure, with clear evidence of an exposure-response relationship. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
1476069X
Volume :
21
Issue :
1
Database :
Complementary Index
Journal :
Environmental Health: A Global Access Science Source
Publication Type :
Academic Journal
Accession number :
157527095
Full Text :
https://doi.org/10.1186/s12940-022-00869-5