Back to Search
Start Over
LRG1 expression reduced inflammation of sepsis-renal injury via activation of NLRP3 inflammasome by HIF-1 alpha.
- Source :
- Molecular & Cellular Toxicology; Jul2022, Vol. 18 Issue 3, p419-429, 11p
- Publication Year :
- 2022
-
Abstract
- Background: Sepsis is a commonly seen severe case in clinical practice and the main cause of health loss worldwide. Objective: We investigated the biological function of LRG1 and its underlying molecular mechanisms in sepsis-renal injury. Mice of sepsis model group were subjected to cecal ligation and puncture (CLP) surgery after anesthetization. THP-1 cell was induced by LPS for vitro model. Results: The mRNA and protein levels of LRG1 in renal tissue of sepsis model were reduced. LRG1 could reduce the inflammation reaction in model of sepsis-renal injury. In addition, LRG1 up-regulation reduced inflammation reaction and ROS production levels in vitro model via the activation of HIF-1α and suppression of NLRP3 inflammasome. Knockout of LRG1 increased inflammation reaction and ROS production levels in vitro model via the inactivation of HIF-1α and induction of NLRP3 inflammasome. Furthermore, the inhibition of HIF-1α reduced the effects of LRG1 on NLRP3 inflammasome in vitro model. Conclusions: The present study suggests that LRG1 expression reduced inflammation of sepsis-renal injury via activation of NLRP3 inflammasome by HIF-1α, thereby may be a promising therapeutic target of sepsis-renal injury. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 1738642X
- Volume :
- 18
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Molecular & Cellular Toxicology
- Publication Type :
- Academic Journal
- Accession number :
- 157431790
- Full Text :
- https://doi.org/10.1007/s13273-021-00214-w