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Clear Cell Carcinoma in the Oral Cavity with Three Novel Types of EWSR1-ATF1 Translocation: A Case Report.

Authors :
Nojima, Satoshi
Kohara, Masaharu
Harada, Hiroshi
Kajikawa, Hitomi
Hirose, Katsutoshi
Nakatsuka, Shin-Ichi
Nakagawa, Yukinobu
Oya, Kaori
Fukuda, Yasuo
Matsunaga, Kazuhide
Uzawa, Narikazu
Fujimoto, Manabu
Toyosawa, Satoru
Morii, Eiichi
Source :
Head & Neck Pathology; Jun2022, Vol. 16 Issue 2, p560-566, 7p
Publication Year :
2022

Abstract

Clear cell carcinoma (CCC) is a rare epithelial malignant tumor of the salivary glands. It is characterized by tumor cells with clear cytoplasm, hyalinized stroma, and most importantly the fusion genes EWSR1-ATF1, EWSR1-CREM, and EWSR1-PLAG1. Break-apart FISH has been performed for multiple CCC cases, but direct sequencing analysis has been performed in relatively few. Herein, we report an interesting case of CCC harboring three EWSR1-ATF1 translocations: EWSR1 exon 8-ATF1 exon 4, EWSR1 exon 7-ATF1 exon 4, and EWSR1 exon 7-ATF1 exon 5. This case indicates the possibility of independent EWSR1-ATF1 gene translocations, and could provide insight into CCC tumorgenesis. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
1936055X
Volume :
16
Issue :
2
Database :
Complementary Index
Journal :
Head & Neck Pathology
Publication Type :
Academic Journal
Accession number :
157411784
Full Text :
https://doi.org/10.1007/s12105-021-01356-y