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Fluorescently Labeled Gadolinium Ferrate/Trigadolinium Pentairon(III) Oxide Nanoparticles: Synthesis, Characterization, In Vivo Biodistribution, and Application for Visualization of Myocardial Ischemia–Reperfusion Injury.
- Source :
- Materials (1996-1944); Jun2022, Vol. 15 Issue 11, p3832-3832, 18p
- Publication Year :
- 2022
-
Abstract
- Various gadolinium compounds have been proposed as contrasting agents for magnetic resonance imaging (MRI). In this study, we suggested a new synthesis method of gadolinium ferrate/trigadolinium pentairon(III) oxide nanoparticles (GF/TPO NPs). The specific surface area of gadolinium ferrate (GdFeO<subscript>3</subscript>) and trigadolinium pentairon(III) oxide (Gd<subscript>3</subscript>Fe<subscript>5</subscript>O<subscript>12</subscript>) nanoparticles was equal to 42 and 66 m<superscript>2</superscript>/g, respectively. The X-ray diffraction analysis confirmed that the synthesized substances were GdFeO<subscript>3</subscript> and Gd<subscript>3</subscript>Fe<subscript>5</subscript>O<subscript>12</subscript>. The gadolinium content in the samples was close to the theoretically calculated value. The free gadolinium content was negligible. Biodistribution of the GF/TPO NPs was studied in rats by fluorescent imaging and Fe<superscript>2+</superscript>/Fe<superscript>3+</superscript> quantification demonstrating predominant accumulation in such organs as lung, kidney, and liver. We showed in the in vivo rat model of myocardial ischemia–reperfusion injury that GF/TPO NPs are able to target the area of myocardial infarction as evidenced by the significantly greater level of fluorescence. In perspective, the use of fluorescently labeled GF/TPO NPs in multimodal imaging may provide basis for high-resolution 3D reconstruction of the infarcted heart, thereby serving as unique theranostic platform. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 19961944
- Volume :
- 15
- Issue :
- 11
- Database :
- Complementary Index
- Journal :
- Materials (1996-1944)
- Publication Type :
- Academic Journal
- Accession number :
- 157370332
- Full Text :
- https://doi.org/10.3390/ma15113832