A four-step protocol for limitation of treatment in terminal care. An observational study in 475 intensive care unit patients.

<bold>Objective: </bold>To describe a four-step protocol for withholding and withdrawal of life support (WH/WDLS) in intensive care unit (ICU) terminal patients.<bold>Design: </bold>Observational study.<bold>Setting: </bold>A 10-bed ICU of a general hospital.<bold>Patients: </bold>Eighty-three patients out of 475 consecutive patients admitted over a 1 year period had WH/WDLS.<bold>Interventions: </bold>The healthcare team chose a pattern of treatment limitation on a four-step protocol for every patient every day. There were four alternatives: group 1: no limitation of care; group 2: patient designated do not resuscitate (DNR) and pressors limited to dopamine at a maximum dose of 20 microg/kg per min; others therapies were continued; group 3: active withdrawal of all therapy except comfort care, i.e., the patient continued to receive nursing, sedation/analgesia, hydration and mechanical ventilation with FIO2=0.21 and no positive end-expiratory pressure (PEEP). Sedation was adjusted to Ramsay 3-4. The group 4 was treated the same as group 3 except that minute ventilation was 5 l/min and sedation/analgesia adjusted to Ramsay 6. WH/WDLS was performed only if the full ICU staff and all family members agreed with the procedure. WH/WDLS was documented in the patient's chart.<bold>Results: </bold>Withholding and withdrawal of life support was performed in 83 patients (17%): 25 patients in group 2 (15 deaths), 36 patients in group 3 (36 deaths) and 22 patients in group 4 (22 deaths). Finally, 73 patients died after WH/WDLS. ICU stay was 10+/-17 days, time from admission to WH/WDLS was 184+407 h and time from WH/WDLS to death was 64+/-84 h.<bold>Conclusion: </bold>This four-step protocol may promote medical decision making on end-of-life care. [ABSTRACT FROM AUTHOR]