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Retention of Neutralizing Response against SARS-CoV-2 Omicron Variant in Sputnik V-Vaccinated Individuals.

Retention of Neutralizing Response against SARS-CoV-2 Omicron Variant in Sputnik V-Vaccinated Individuals.

Authors :
Lapa, Daniele
Grousova, Daria M.
Matusali, Giulia
Meschi, Silvia
Colavita, Francesca
Bettini, Aurora
Gramigna, Giulia
Francalancia, Massimo
Garbuglia, Anna Rosa
Girardi, Enrico
Puro, Vincenzo
Antinori, Andrea
Kovyrshina, Anna V.
Dolzhikova, Inna V.
Shcheblyakov, Dmitry V.
Tukhvatulin, Amir I.
Zubkova, Olga V.
Gushchin, Vladimir A.
Logunov, Denis Y.
Naroditsky, Boris S.
Source :
Vaccines; May2022, Vol. 10 Issue 5, p817-817, 9p
Publication Year :
2022

Abstract

The new Omicron variant of SARS-CoV-2, first identified in November 2021, is rapidly spreading all around the world. Omicron has become the dominant variant of SARS-CoV-2. There are many ongoing studies evaluating the effectiveness of existing vaccines. Studies on the neutralizing activity of vaccinated sera against the Omicron variant are currently being carried out in many laboratories. In this study, we have shown the neutralizing activity of sera against the SARS-CoV-2 Omicron variant compared to the reference Wuhan D614G variant in individuals vaccinated with two doses of Sputnik V up to 6 months after vaccination and in individuals who experienced SARS-CoV-2 infection either before or after vaccination. As a control to our study we also measured neutralizing antibody titers in individuals vaccinated with two doses of BNT162b2. The decrease in NtAb titers to the Omicron variant was 8.1-fold for the group of Sputnik V-vaccinated individuals. When the samples were stratified for the time period after vaccination, a 7.6-fold or 8.8-fold decrease in NtAb titers was noticed after up to 3 and 3-to-6 months after vaccination. We observed a 6.7- and 5-fold decrease in Sputnik V-vaccinated individuals experiencing asymptomatic or symptomatic infection, respectively. These results highlight the observation that the decrease in NtAb to the SARS-CoV-2 Omicron variant compared to the Wuhan variant occurs for different COVID-19 vaccines in use, with some showing no neutralization at all, confirming the necessity of a third booster vaccination. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
2076393X
Volume :
10
Issue :
5
Database :
Complementary Index
Journal :
Vaccines
Publication Type :
Academic Journal
Accession number :
157249547
Full Text :
https://doi.org/10.3390/vaccines10050817