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Gastro-Protective Effect of Fermented Soybean (Glycine max (L.) Merr.) in a Rat Model of Ethanol/HCl-Induced Gastric Injury.
- Source :
- Nutrients; May2022, Vol. 14 Issue 10, p2079-2079, 10p
- Publication Year :
- 2022
-
Abstract
- The present research purposed to examine the gastro-protective effect of Glycine max (L.) Merr. fermented using Lactobacillus delbrueckii ssp. delbrueckii Rosell-187 (Gastro-AD<superscript>®</superscript>) on ethanol/HCl-induced gastric damage, specifically on gastric acid secretion. After oral supplementation of Gastro-AD<superscript>®</superscript> to Sprague–Dawley (SD) rats with ethanol/HCl-induced gastric damage, we determined that Gastro-AD<superscript>®</superscript> attenuated the gastric mucosal lesion, hemorrhage and gastric acid secretion induced by ethanol/HCl. In addition, we observed that the Gastro-AD<superscript>®</superscript> treatment increased the serum prostaglandin E2 level and decreased the levels of gastric acid secretion-related receptors in both gastric tissues and primary gastric parietal cells. Furthermore, it decreased the levels of inflammatory factors, including serum histamine and expression of p-IκB, p-p65, iNOS and COX-2 and the activity of apoptotic signaling pathways, including those involving p-JNK, Bcl2/Bax, Fas, FADD, caspase-8 and caspase-3, in the stomach of the ethanol/HCl-treated rats. Thus, we suggest that Gastro-AD<superscript>®</superscript> supplementation may reduce ethanol/HCl-induced gastric acid secretion and prevent gastric injury. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 20726643
- Volume :
- 14
- Issue :
- 10
- Database :
- Complementary Index
- Journal :
- Nutrients
- Publication Type :
- Academic Journal
- Accession number :
- 157241118
- Full Text :
- https://doi.org/10.3390/nu14102079