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Glutathione‐Responsive Heterogeneous Metal–Organic Framework Hybrids for Photodynamic‐Gene Synergetic Cell Apoptosis.
- Source :
- Chemistry - A European Journal; Jun2022, Vol. 28 Issue 31, p1-5, 5p
- Publication Year :
- 2022
-
Abstract
- Keywords: biosensors; glutathione; heterogeneous structures; metal-organic frameworks; singlet oxygen EN biosensors glutathione heterogeneous structures metal-organic frameworks singlet oxygen 1 5 5 06/06/22 20220601 NES 220601 A core-shell heterogeneous metal-organic framework (MOF) hybrid is sequentially designed by a photosensitized porous coordination network (PCN)-typed MOF as core and Cu SP 2+ sp -centered zeolitic imidazolate framework (ZIF-67) as shell encapsulating cyanine 3-labelled siRNA. Taking together, these results manifested that intracellular GSH could be consumed to trigger PSZ for the PDT-assisted gene synergistic therapy, achieving the comprehensive cell apoptosis via the synergistic GSH-controlled siRNA release, GSH depletion and promoted SP 1 sp O SB 2 sb generation. In addition to the GSH-responsive siRNA release and fluorescence enhancement, the GSH unlocking effect on SP 1 sp O SB 2 sb production was also explored for purpose of controllable PDT by monitoring the enhanced fluorescence at 525 nm of a SP 1 sp O SB 2 sb indicator named singlet oxygen sensor green (SOSG). Moreover, the siRNA-encapsulated ZIF-67 (S-ZIF67) without PCN core realized the cellular GSH scavenging similarly, whereas the bare PCN revealed no obvious effect on GSH depletion. [Extracted from the article]
- Subjects :
- NANOMEDICINE
METAL-organic frameworks
APOPTOSIS
Subjects
Details
- Language :
- English
- ISSN :
- 09476539
- Volume :
- 28
- Issue :
- 31
- Database :
- Complementary Index
- Journal :
- Chemistry - A European Journal
- Publication Type :
- Academic Journal
- Accession number :
- 157235767
- Full Text :
- https://doi.org/10.1002/chem.202200305