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Neuroprotective Mechanisms of Ginsenoside Rb1 in Central Nervous System Diseases.

Neuroprotective Mechanisms of Ginsenoside Rb1 in Central Nervous System Diseases.

Authors :
Gong, Liang
Yin, Jiayi
Zhang, Yu
Huang, Ren
Lou, Yuxuan
Jiang, Haojie
Sun, Liyan
Jia, Jinjing
Zeng, Xiansi
Source :
Frontiers in Pharmacology; 6/2/2022, Vol. 13, p1-12, 12p
Publication Year :
2022

Abstract

Panax ginseng and Panax notoginseng, two well-known herbs with enormous medical value in Asian countries, have a long usage history in China for the therapy of some diseases, such as stroke. Ginsenoside Rb1 is one of most important active ingredients in Panax ginseng and Panax notoginseng. In the last two decades, more attention has focused on ginsenoside Rb1 as an antioxidative, anti-apoptotic and anti-inflammatory agent that can protect the nervous system. In the review, we summarize the neuroprotective roles of ginsenoside Rb1 and its potential mechanisms in central nervous system diseases (CNSDs), including neurodegenerative diseases, cerebral ischemia injury, depression and spinal cord injury. In conclusion, ginsenoside Rb1 has a potential neuroprotection due to its inhibition of oxidative stress, apoptosis, neuroinflammation and autophagy in CNSDs and may be a promising candidate agent for clinical therapy of CNSDs in the future. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
16639812
Volume :
13
Database :
Complementary Index
Journal :
Frontiers in Pharmacology
Publication Type :
Academic Journal
Accession number :
157229088
Full Text :
https://doi.org/10.3389/fphar.2022.914352