Hydrogen Sulfide-Induced Vasodilation: The Involvement of Vascular Potassium Channels.

Hydrogen sulfide (H₂S) has been highlighted as an important gasotransmitter in mammals. A growing number of studies have indicated that H₂S plays a key role in the pathophysiology of vascular diseases and physiological vascular homeostasis. Alteration in H₂S biogenesis has been reported in a variety of vascular diseases and H₂S supplementation exerts effects of vasodilation. Accumulating evidence has shown vascular potassium channels activation is involved in H₂S-induced vasodilation. This review aimed to summarize and discuss the role of H₂S in the regulation of vascular tone, especially by interaction with different vascular potassium channels and the underlying mechanisms. [ABSTRACT FROM AUTHOR]