Alkylresorcinols as an Indicator of Whole-Grain Intake and Its Relation to Colorectal Carcinoma.

BACKGROUND: Alkylresorcinols are phenolic lipids that exclusively present in the outer parts of wheat and rye grains. They have been proposed as specific dietary biomarkers of whole-grain wheat and rye intake. Dietary fibers protective role aganist colorectal cancer has been postulated several decades ago. AIM: To verify the relation of dietary fiber intake and incidence of colorectal cancer using plasma total Alkylresorcinols concentrations as an indicator of whole-grain intake. METHODS: 148 Subjects were enrolled and categorixed into two groups; Group (A): 62 patients with colorectal cancer and Group (B): 86 subjects with normal colonoscopy "control group". Blood samples were withdrawn from the patients after overnight fasting for detection of Alkylresorcinols levels. RESULTS: Detection of the Alkylresorcinols levels; C17, C21 and Total Cs were significantly higher in the control group in comparison to colorectal cancer group, C19 levels showed no significant difference. CONCLUSION: People with high intake of fibers especially cereals probably have a lower risk of developing cancer colon. [ABSTRACT FROM AUTHOR]