Back to Search
Start Over
SARS-CoV-2 serology after COVID-19 in multiple sclerosis: An international cohort study.
- Source :
- Multiple Sclerosis Journal; Jun2022, Vol. 28 Issue 7, p1034-1040, 7p
- Publication Year :
- 2022
-
Abstract
- Background: The MuSC-19 project is an Italian cohort study open to international partners that collects data on multiple sclerosis (MS) patients with COVID-19. During the second wave of the pandemic, serological tests became routinely available. Objective: To evaluate the seroprevalence of anti-SARS-CoV-2 antibodies according to the use of disease-modifying therapy (DMT) in a subset of patients included in the MuSC-19 data set who had undergone a serological test. Methods: We evaluated the association between positive serological test results and time elapsed since infection onset, age, sex, Expanded Disability Status Scale score, comorbidities and DMT exposure using a multivariable logistic model. Results: Data were collected from 423 patients (345 from Italy, 61 from Turkey and 17 from Brazil) with a serological test performed during follow-up. Overall, 325 out of 423 tested patients (76.8%) had a positive serological test. At multivariate analysis, therapy with anti-CD20 was significantly associated with a reduced probability of developing antibodies after COVID-19 (odds ratio (OR) = 0.20, p = 0.002). Conclusion: Patients with MS maintain the capacity to develop humoral immune response against SARS-COV-2, although to a lesser extent when treated with anti-CD20 drugs. Overall, our results are reassuring with respect to the possibility to achieve sufficient immunization with vaccination. [ABSTRACT FROM AUTHOR]
- Subjects :
- COVID-19
MULTIPLE sclerosis
SERODIAGNOSIS
SARS-CoV-2
HUMORAL immunity
Subjects
Details
- Language :
- English
- ISSN :
- 13524585
- Volume :
- 28
- Issue :
- 7
- Database :
- Complementary Index
- Journal :
- Multiple Sclerosis Journal
- Publication Type :
- Academic Journal
- Accession number :
- 157071176
- Full Text :
- https://doi.org/10.1177/13524585211035318