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SARS-CoV-2 serology after COVID-19 in multiple sclerosis: An international cohort study.

Authors :
Sormani, Maria Pia
Schiavetti, Irene
Landi, Doriana
Carmisciano, Luca
De Rossi, Nicola
Cordioli, Cinzia
Moiola, Lucia
Radaelli, Marta
Immovilli, Paolo
Capobianco, Marco
Brescia Morra, Vincenzo
Trojano, Maria
Tedeschi, Gioacchino
Comi, Giancarlo
Battaglia, Mario Alberto
Patti, Francesco
Fragoso, Yara Dadalti
Sen, Sedat
Siva, Aksel
Furlan, Roberto
Source :
Multiple Sclerosis Journal; Jun2022, Vol. 28 Issue 7, p1034-1040, 7p
Publication Year :
2022

Abstract

Background: The MuSC-19 project is an Italian cohort study open to international partners that collects data on multiple sclerosis (MS) patients with COVID-19. During the second wave of the pandemic, serological tests became routinely available. Objective: To evaluate the seroprevalence of anti-SARS-CoV-2 antibodies according to the use of disease-modifying therapy (DMT) in a subset of patients included in the MuSC-19 data set who had undergone a serological test. Methods: We evaluated the association between positive serological test results and time elapsed since infection onset, age, sex, Expanded Disability Status Scale score, comorbidities and DMT exposure using a multivariable logistic model. Results: Data were collected from 423 patients (345 from Italy, 61 from Turkey and 17 from Brazil) with a serological test performed during follow-up. Overall, 325 out of 423 tested patients (76.8%) had a positive serological test. At multivariate analysis, therapy with anti-CD20 was significantly associated with a reduced probability of developing antibodies after COVID-19 (odds ratio (OR) = 0.20, p = 0.002). Conclusion: Patients with MS maintain the capacity to develop humoral immune response against SARS-COV-2, although to a lesser extent when treated with anti-CD20 drugs. Overall, our results are reassuring with respect to the possibility to achieve sufficient immunization with vaccination. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
13524585
Volume :
28
Issue :
7
Database :
Complementary Index
Journal :
Multiple Sclerosis Journal
Publication Type :
Academic Journal
Accession number :
157071176
Full Text :
https://doi.org/10.1177/13524585211035318