Microalbuminuria: A novel risk indicator for cardiac morbidity and mortality.

Background: There is a relative paucity of data on the link between urine microalbumin andIHD in non-diabetics as well as non-hypertensives compared to diabetics. Thisstudy was meant to look for the association between urine microalbuminandincardiacmorbidityandmortalityamongnon-diabeticandnon-hypertensives, which may further provide insight to the early diagnosis of microalbuminuria and its potential for predicting cardiac morbidity and thus neededinputs for better clinicalmanagement. Aims and objectives: To assessthe relationshipbetween microalbuminuria and proven riskfactors and markersof cardiovascular disease in non-diabetic& nonhypertensiveischaemic heartdiseasepatients. Materials and methods: Among the 200 patients which were taken in the study, 141 (69.8%)weremalesandthe rest29.2%were females. 34.5% each were from the ageof 41-50 years and51-60 yearsrespectively. Only 26 (13.0%) patients were from the age group of morethan60years. Results: Themean ageofpatients was50.66 withaSDof9.33. Majorityofmaleswerefrom theagegroupof41-50years(38.3%),while42.4%of femaleswere fromthe age groupof51- 60years. Meanageofmalepatientswasfoundtobe49.41±9.16,while female patientswasof 52.44±9.57. Chestpainremains themostcommoncomplaintamongthepatients(100%),followedbybreathlessnessin 55%andpalpitationin27.5%. MostofthepatientswerehavingaBMIofmorethan23kg/sq.i.e.,107(53.5%),followedby44.5%wit hanormalvalue Mean serum cholesterol among patients was176.7 mg/dl, while meanserum TGs was 131.7 mg/dl. Mean blood sugar level was around 118.9mg/dl. Ejectionfractionoflessthan50%wasobservedin132patients,constituting to66.0%of the totalstudysubjects. Microalbuminuria detected in 73.0% of the patients as perthe criteria of30-300usingurinaryACR. Out of146 patients with microalbuminuria, 102 (69.9%) were males andtherest44(30.1%)were females. Among the patient having MA, 129 (88.4%) were fromless than 60 years ofage andtherestwere above 60 yearsofage. 45.9%ofthepatienthavingmicroalbuminuriawerehavingnormalBMI. Around74%ofthepatientswithraised serumureahadincidenceof micro albuminuria. Among52patientswithelevatedserumcreatinine,37i.e.,71.1%hadmicro albuminuria. Among169patientswithTGlevelsmorethan125mg/dl,125(73.9%)werehavingmicroalbuminuria . Among26patientswithSerumcholesterollevelsmorethan200mg/dl,20 (76.9%)werehaving microalbuminuria. Among 63 patients with blood sugar levels above 126 mg/dl, 42 (66.6%)werehavingMicroalbuminuria, EF of less than 50% was observed in 132 (66%) of the patients. In 146patients with micro albuminuria, 98 (67.1%) were having EF of less than50%. Conclusion:Urinary MA can beusedas animportant isolatedindicatorforassessingmorbidityandmortalityandsurvivalincardiovascular diseases amongst the patients who are not a known case of HTNand diabetesanddevelopIschaemic heartdisease. [ABSTRACT FROM AUTHOR]