Back to Search
Start Over
Toxicity and Antiulcer Properties of Ipomoea wightii (Wall.) Choisy Leaves: An In Vivo Approach Using Wistar Albino Rats.
- Source :
- Evidence-based Complementary & Alternative Medicine (eCAM); 5/18/2022, p1-14, 14p, 1 Color Photograph, 1 Diagram, 6 Charts, 2 Graphs
- Publication Year :
- 2022
-
Abstract
- Humans have been using herbs to prevent and cure various ailments since antiquity, and Ipomoea wightii is a significant medicinal plant known for its wide ethnobotanical uses. Although the plant is known to treat ulcers, there is no significant scientific validation. The present study aimed to assess the acute toxicity, subacute toxicity, and antiulcer properties of the leaf methanol extract of I. wightii (IWL). In the subacute study, the extracts were given orally at 100, 200, and 400 mg/kg doses for 28 days, and we analyzed the biochemical and histological parameters to evaluate the toxicity of IWL. Two different models were assessed to explore antiulcer properties, such as indomethacin- and ethanol-induced ulcer model. Ulcer areas and ulceration percentage histopathology of the stomach were used to study the efficacy of extracts. The acute toxicity study showed that IWL was safe to the maximum dose of 2000 mg/kg body weight. In a subacute toxicity study, the oral administration of IWL did not produce any mortality in the tested animals. The analysis of haematological, liver biochemical, kidney profile, lipid profile, and in vivo antioxidant parameters depicted that all the values were within the control limits after the experimental period and were considered nontoxic to animals. Additionally, the antiulcer study demonstrated a positive response of IWL in a dose-related manner (indomethacin- and ethanol-induced models). Macroscopic analysis showed that pretreatment with I. wightii leaf methanol extract significantly reduced the gastric lesion and decreased the ulceration area (14.52 mm<superscript>2</superscript>), demonstrating superior results to the positive control group (27.71 mm<superscript>2</superscript>). The histopathological analysis revealed that pretreatment with a high dose of 400 mg/kg of I. wightii leaf methanol extract and positive control group (omeprazole) markedly protected pathological effects, and the gastric mucosa appeared normal. In conclusion, I. wightii has solid nontoxic potential as a promising native herb for an integral therapy for the treatment of ulcers. [ABSTRACT FROM AUTHOR]
- Subjects :
- PEPTIC ulcer prevention
BIOCHEMISTRY
BIOLOGICAL models
MEDICINAL plants
IN vivo studies
KIDNEYS
ANIMAL experimentation
METHANOL
ORAL drug administration
LIVER
INDOMETHACIN
ANTIOXIDANTS
RATS
COMPARATIVE studies
LEAVES
DOSE-effect relationship in pharmacology
TOXICITY testing
DESCRIPTIVE statistics
OMEPRAZOLE
PLANT extracts
HISTOLOGY
ETHANOL
PEPTIC ulcer
BLOOD testing
ANTIULCER drugs
GASTRIC mucosa
DRUG toxicity
LIPIDS
PHARMACODYNAMICS
Subjects
Details
- Language :
- English
- ISSN :
- 1741427X
- Database :
- Complementary Index
- Journal :
- Evidence-based Complementary & Alternative Medicine (eCAM)
- Publication Type :
- Academic Journal
- Accession number :
- 156944518
- Full Text :
- https://doi.org/10.1155/2022/4328571