Extreme cardiovascular risk—do we need a new risk category?

The very high-risk category includes both patients without documented CVD but with a very high probability of a cardiovascular event due to existing risk factors, as well as patients with previously diagnosed CVD and/or patients who have had a cardiovascular event.[1] The latter group of patients is also very heterogeneous, as it includes patients with various comorbidities and varying degrees of CVD progression, which are not mentioned in the risk categories. Furthermore, we strongly believe, based on EBM, that broadening the population of patients in whom LDL-C should be lowered so much will positively influence the effectiveness of therapy and consequently improve the prognosis in this most burdened group of patients. Cardiovascular disease (CVD) remains the most common cause of death worldwide.[1] Low-density lipoprotein cholesterol (LDL-C) is the most important risk factor for atherosclerosis and plays a significant role in the development of atherosclerotic CVD (ASCVD). [Extracted from the article]