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Immunological parameters associated with the severity of COVID-19 pneumonia in kidney transplant recipients.
- Source :
- International Urology & Nephrology; May2022, Vol. 54 Issue 5, p1105-1116, 12p
- Publication Year :
- 2022
-
Abstract
- Purpose: An outbreak of a novel respiratory disease due to coronavirus species was emerged in 2019 and named as Coronavirus Disease-2019 (COVID-19). Clinical and immunological factors affecting the course of COVID-19 in kidney transplant recipients (KTR) are not well-known. Methods: In this prospective observational study, we presented 20 KTR with COVID-19 pnemonia and examined the factors predicting the severity of COVID-19. A total of 10 KTR without COVID-19 was used as control group. Lymphocyte subsets were determined by flow cytometry. In 13/20 patients, immunophenotyping was repeated 1 week later. Results: Mean age of the patients was 50 ± 9 years. Patients were classified as mild–moderate (oxygen saturation: SO<subscript>2</subscript> > 90%) and severe disease groups (SO<subscript>2</subscript> ≤ 90%). Serum albumin and hemoglobin were lower and CRP, fibrinogen and peak d-dimer were higher in severe group. Peak CRP was inversely associated with nadir SO<subscript>2</subscript> (r = − 0.68, p = 0.001). Neutrophil/lymphocyte ratio was higher in severe group (p = 0.01). CD3 + and CD4 + cells were lower and NK cell percentage (CD16 + 56 +) was higher in severe group. Percentage of spontaneously activated CD8 cells (CD8 + CD69 +) was higher in severe group. In comparison of KTR with and without COVID-19, CD8 + cells were lower but NK cell percentage was higher in KTR with COVID-19. Conclusion: In this pilot study, increased NK cells, activated CD8 + cells and decreased CD3 + and CD4 + cells were associated with severity of COVID-19 in KTR. Peripheral immunophenotyping of lymphocyte subtypes may provide prognostic information about the clinical course of COVID-19 in KTR. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 03011623
- Volume :
- 54
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- International Urology & Nephrology
- Publication Type :
- Academic Journal
- Accession number :
- 156743296
- Full Text :
- https://doi.org/10.1007/s11255-021-02947-y