Clinical and Para-Clinical Comparison of Complicated and Uncomplicated Brucellosis in Patients Referred to Imam Hossein Hospital since 2001 to 2017.

Background: Brucellosis is one of the most prevalent zoonoses, with an annual incidence of half a million cases globally. Most parts of Iran are endemic for Brucellosis. Given the worse prognosis, knowledge and early diagnosis of the complicated forms is especially important. The present study aimed to identify the clinical and paraclinical predictive alarms for complications in Brucellosis. Materials and Methods: This study was done as a retrospective study on records of inpatients suffering active Brucellosis in Imam Hussein Medical Center, SBMU, Tehran in 15 years (2001April-2016 March) as the census. Epidemiological, clinical, and laboratory data were collected in the formerly prepared questionnaire. According to their clinical and paraclinical findings, cases were studied in two groups: Complicated and Uncomplicated. All data were analyzed and compared using SPSS version 19.0 ANOVA and K2 tests (P values < 0.05). Results: In 95 patients suffering Brucellosis, 56 (59%) were male, and 39 (41%) were female. 69 (73%) cases were evaluated as uncomplicated, and 26 (28%) cases were as complicated. 11(28%) of females and 20 (35%) male cases were complicated without significant statistical difference. Arthritis was the most common form, followed by the nervous system. The mean patient age was 35.46-22.2 years, (ranging 1-86) with no difference in two groups and different complications. The frequency of the previous history of Brucellosis and unpasteurized dairy product use was more common in complicated cases but was not significant. Myalgia (92% vs. 50%) and fever (50% vs. 9%) were significantly more common in complicated Brucellosis. Lab test results had no significant mathematical difference. Conclusion: Myalgia and fever were significantly more common in complicated Brucellosis. There was no significant difference in other classical symptoms of Brucellosis as sweating, malaise, fatigue, and chills between the two groups and no significant difference in serologic tests titer and lab tests. [ABSTRACT FROM AUTHOR]