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Alleviative effects of foraging exercise on depressive-like behaviors in chronic mild stress-induced ischemic rat model.
- Source :
- Brain Injury; 2022, Vol. 36 Issue 1, p127-136, 10p
- Publication Year :
- 2022
-
Abstract
- Poststroke depression (PSD) is a common complication that seriously affects the functional recovery and prognosis of an individual. As some patients with PSD fail to respond to drug therapy, it is urgent to find a viable alternative treatment. An active exercise program known as foraging exercise (FE), using food as bait, was designed. First, focal ischemia and chronic unpredictable mild stress (CUMS) were used to establish a PSD model in rats. FE was then performed for 4 weeks. Body weight and behavioral assessments were conducted at the end of the 4<superscript>th</superscript> and 8<superscript>th</superscript> weeks. After 8 weeks, the results revealed that, compared with the PSD group, the behavioral scores of the rats in the PSD/FE group were significantly improved, the expression of Iba-1 in the affected frontal lobe and striatum was decreased, and serum levels of IL-6 and the IL-6/IL-10 ratio were downregulated. However, the ratio of residual brain volume in rats that had experienced CUMS was significantly less than that in the stroke group. FE can alleviate the behavioral scores of PSD rats, and its mechanism may be related to a modulation of the immune-inflammation response of microglia. Furthermore, chronic, persistent stress may increase the volume of cerebral infarction after stroke. [ABSTRACT FROM AUTHOR]
- Subjects :
- PREVENTION of mental depression
BIOLOGICAL models
STATISTICS
BODY weight
ANALYSIS of variance
ISCHEMIC stroke
ANIMAL experimentation
EXERCISE physiology
RATS
T-test (Statistics)
EXERCISE
DESCRIPTIVE statistics
ENZYME-linked immunosorbent assay
DATA analysis software
DATA analysis
DISEASE complications
Subjects
Details
- Language :
- English
- ISSN :
- 02699052
- Volume :
- 36
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Brain Injury
- Publication Type :
- Academic Journal
- Accession number :
- 156475344
- Full Text :
- https://doi.org/10.1080/02699052.2022.2034949