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Immune response to hepatitis B vaccination in human immunodeficiency virus‐positive patients in China: A 2‐year retrospective study.
- Source :
- Journal of Medical Virology; Jun2022, Vol. 94 Issue 6, p2684-2693, 10p
- Publication Year :
- 2022
-
Abstract
- Currently, the studies focused on the immune response to hepatitis B vaccination in Chinese human immunodeficiency virus (HIV)‐positive patients are limited. In this study, the participants with an initial hepatitis B surface antibody (HBsAb) titer <10 mIU/ml were assigned to Cohort 1 to receive a standard dose of recombinant hepatitis B vaccine, and participants with an initial HBsAb titer between 10 and 100 mIU/ml were assigned to Cohort 2 to receive a single reinforced recombinant vaccine. In Cohort 1, the immune and high response rates in HIV‐positive patients were 93.4%/81.4%, 87.4%/51.5%, and 83.2%/40.7% at 1–3 months, 1 year, and 2 years postvaccination. Multivariate analysis showed that only age and HIV RNA status at baseline were independent factors related to sustained immune response at 2 years postvaccination. In Cohort 2, the high immune response rates in HIV‐positive patients were 78.8%, 60.6%, and 51.5% at 1–3 months, 1 year, and 2 years postvaccination. The immune or high response rates did not differ between HIV‐positive patients and healthy controls at 1–3 months postvaccination in these two cohorts; however, HBsAb titers were significantly lower in HIV‐positive patients. This study summarized the 2‐year data of immune response to hepatitis B vaccination and analyzed the factors related to sustained immune response at 2 years postvaccination in Chinese HIV‐positive patients. Highlights: Observation of the immune response to hepatitis B vaccination in Chinese HIV‐positive patientsTwo Cohorts were enrolled in this study: (1) the participants with an initial HBsAb titer < 10 mIU/ml were assigned to Cohort 1 to receive a standard dose of recombinant hepatitis B vaccine, (2) the participants with an HBsAb titer between 10 and 100 mIU/ml were assigned to Cohort 2 to receive a single reinforced recombinant vaccineTwo‐year immune response and high immune response rates in these 2 Cohorts were summarized.The factors related to sustained immune response at 2 years postvaccination in Chinese HIV‐positive patients were analyzed. [ABSTRACT FROM AUTHOR]
- Subjects :
- HEPATITIS B vaccines
IMMUNE response
HIV
HIV-positive persons
HEPATITIS B
Subjects
Details
- Language :
- English
- ISSN :
- 01466615
- Volume :
- 94
- Issue :
- 6
- Database :
- Complementary Index
- Journal :
- Journal of Medical Virology
- Publication Type :
- Academic Journal
- Accession number :
- 156362942
- Full Text :
- https://doi.org/10.1002/jmv.27523