Antioxidant Effects of 1,8-Cineole Against Long Term DL-Polychlorinated Biphenyls (PCBs) Toxicity in Domestic Hen's Liver.

Current study was aimed to investigate 1,8-Cineole effectiveness as antioxidant defense against dioxins like compound polychlorinated biphenyls (dl-PCBs) toxicity in hen's liver. Domestic hens (n=45) were divided randomly and equally into 3 equal groups. 1st group (control) was given weekly for 6 months orally by gavage corn oil as carrier and feed on normal chicken pellets, 2nd group were given orally by gavage weekly for 6 months PCBs at dose 2 g/kg weekly dissolved freshly in corn oil and evaporated to nitrogen, 3rd group (PCBs+cineole) and acetone mixed 2 g/kg B. W./weekly PCBs + Cineole 1000mg/kg/weekly for 6 months. Half of liver sample were taken for histopathological examination at end of experiment and the other half liver for biochemical assay. In liver thiobarbituric acid reactive substances (TBARS), reduced glutathione (GSH) and catalase (CAT). Results showed that significant increase P<0.05 in TBARS at 2nd group when compared with control and 3rd group, while CAT and GSH indicated significant P<0.05 decreased at 2nd group compared with control and 3rd group. Histopathological changes in the hen's liver at 6 months revealed no important pathological changes in control and 3rd group, while 2nd group (PCBs) showed necrosis, hetrophiles and mononuclear cell infiltration, severe granulation tissue in hepatocyte, disorganization of liver and liver adenoma. [ABSTRACT FROM AUTHOR]