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The diagnostic value of 123I-IMP SPECT in ocular adnexal lymphoma.
- Source :
- International Ophthalmology; Apr2022, Vol. 42 Issue 4, p1205-1212, 8p
- Publication Year :
- 2022
-
Abstract
- Background: N-isopropyl- (<superscript>123</superscript>I) p-iodoamphetamine (<superscript>123</superscript>I-IMP) is specifically accumulated in primary central nervous system lymphoma (PCNSL) during single-photon emission tomography (SPECT) and contributes to its diagnostic imaging. However, whether <superscript>123</superscript>I-IMP is accumulated in ocular adnexal lymphoma (OAL), one of the malignant intraorbital tumors, remains unclear. This study aimed to evaluate the diagnostic value of <superscript>123</superscript>I-IMP SPECT in OAL. Methods: Between August 2005 and June 2020, 26 patients with intraorbital tumors underwent neurosurgery at the tertiary care center. Of these, 15 patients who underwent <superscript>123</superscript>I-IMPSPECT before surgery were retrospectively examined. The region of interest was set in the cerebellum ipsilateral to the intraorbital tumor on <superscript>123</superscript>I-IMP SPECT, and the tumor-to-cerebellum ratio (T/C ratio) was calculated using the following formula: T/C ratio = [accumulation of tumor (count/pixel)]/[accumulation of ipsilateral normal cerebellar hemisphere (count/pixel)]. Results: Six patients were included in the OAL group, who were pathologically diagnosed with extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma), diffuse large B-cell lymphoma (DLBCL), and plasmacytoma. The T/C ratio in the OAL group was statistically higher than that in the non-OAL group (p < 0.01). The optimal cutoff values for both groups were between 0.76 and < 0.93. The sensitivity and specificity were 1.00, respectively. Conclusions: <superscript>123</superscript>I-IMP SPECT is useful as one of the examinations in the differential diagnoses of OAL, because it showed a significantly higher accumulation in OAL group than in non-OAL group. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01655701
- Volume :
- 42
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- International Ophthalmology
- Publication Type :
- Academic Journal
- Accession number :
- 156221955
- Full Text :
- https://doi.org/10.1007/s10792-021-02105-4