Metal-organic frameworks/polydopamine coating endows polyetheretherketone with disinfection and osteogenicity.

The work describes a polydopamine-wrapped zeolitic imidazolate framework-8 (ZIF-8) coating constructed on the sulfonated polyetheretherketone (PEEK). The coating is not only conducive to the controllable Zn²⁺ releases, but also exhibits excellent photothermal capacity under near-infrared (NIR) irradiation. in vitro antibacterial experiments indicate the coating possesses bactericidal efficiencies of 100% against Staphylococcus aureus and Escherichia coli under NIR. Without NIR, the ZIF-8/pDA-functionalized substrate shows favorable biocompatibility and enhanced osteogenic activities. We are convinced that this study may provide prospective opinions for developing the PEEK implants with photoinduced disinfection and osteogenesis for the repair of infected bone defects. [ABSTRACT FROM AUTHOR]