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Global epidemiology of childhood bone and joint infection: a systematic review.
- Source :
- Infection; Apr2022, Vol. 50 Issue 2, p329-341, 13p, 5 Charts
- Publication Year :
- 2022
-
Abstract
- Purpose: Childhood bone and joint infection (BJI) is a potentially severe disease that may have permanent sequelae, including growth impairment and limb deformity. It has been characterised in the literature with a focus on Western epidemiology; there are currently no reports detailing global epidemiology and bacteriology. This omits key data from determining temporal trends, appropriate antibiotic therapy, and resource allocation. This review aims to identify studies that characterise the incidence of childhood bone and joint infection or provide detailed bacteriology within their region. Methods: A systematic review of the literature was performed from 01/01/1980 to 31/12/2020. Data has been analysed to give incidence of disease per 100,000 children, primary pathogen by country where available, and risk ratio (RR) for disease by ethnicity. This is applicable for areas that experience race-related inequitable burden of disease. Results: Forty-four articles met the inclusion area; of these, seven were population-wide studies, primarily from Europe or the United States, and the remainder were cohort studies. Incidence could be derived from 26 studies compromising over 34, 000 children. Information on bacteriology was available from 39 publications (10, 957 cases). Methicillin-sensitive Staphylococcus aureus is the most common pathogen in the West. Recently, disease secondary to Kingella kingae and methicillin-resistant S. aureus has increased. Salmonella remains a dominant pathogen in African regions. Increased risk of disease is observed in Aboriginal, New Zealand Māori, Pacific, Indigenous Fijian, and Bedouin children. Conclusion: The current state of the literature detailing incidence of childhood BJI focuses on disease patterns from the West. There is a paucity of high-quality publications in the developing world. Despite these limitations, global trends in burden of disease show race-related inequitable risk of BJI. Temporal and regional variation in bacteriology can be demonstrated. Level of evidence: III. [ABSTRACT FROM AUTHOR]
- Subjects :
- BACTERIAL disease risk factors
BONE diseases
CINAHL database
INFECTIOUS arthritis
MEDICAL databases
INFORMATION storage & retrieval systems
SYSTEMATIC reviews
RACE
DISEASE incidence
METHICILLIN-resistant staphylococcus aureus
STAPHYLOCOCCUS aureus
GRAM-negative aerobic bacteria
SALMONELLA
BACTERIAL diseases
ODDS ratio
ETHNIC groups
INDIGENOUS peoples
MEDLINE
CHILDREN
Subjects
Details
- Language :
- English
- ISSN :
- 03008126
- Volume :
- 50
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Infection
- Publication Type :
- Academic Journal
- Accession number :
- 155912991
- Full Text :
- https://doi.org/10.1007/s15010-021-01741-3