Study on Diagnosis of Fetal Intrauterine Hypoxia in Pregnant Women with Hypertension During Pregnancy Based on 3D-CPA.

This article explored the relationship between intrauterine hypoxia in pregnant women with pregnancy-induced hypertension and the changes in brain and placental parameters detected by three-dimensional power Doppler (3D-CPA). One hundred confirmed pregnant women with hypertension during pregnancy were selected as the case group, and 100 pregnant women with normal pregnancy in the same period were selected as the control group. 3D-CPA was used to examine the fetal brain and placental blood perfusion parameters of the two groups, and the two groups of fetal delivery were detected after the level of oxidative stress products in cord blood, the correlation between 3D-CPA parameters and oxidative stress products was analyzed. The blood vessel index (VI), blood flow index (FI), and vascular blood flow index (VFI) measured values in the placenta tissue of the case group were lower than those of the control group (P<0.05). VI, FI, VFI measured value in the fetal brain of the case group was greater than that of the control group (P<0.05). The measured values of VI; FI, and VFI in the placental tissue of the preeclampsia group were lower than those of the hypertensive disorder group during pregnancy (P<0.05). The measured values of FI, VFI and VI in the fetal brain of the preeclampsia group were greater than those of the hypertensive disease group during pregnancy (P<0.05). The cord blood of the case group contained malondialdehyde (MDA), 8-isoprostaglandin (8-iso), Oxidized low-density lipoprotein (ox-LDL) and heat shock protein-70 (HSP-70) were significantly higher than those of the control group (P<0.05). The VI and VFI in the placenta tissue of patients with pregnancy-induced hypertension were significantly negatively correlated with the levels of MDA, ox-LDL, 8-iso, and HSP-70 in the patient's cord blood (P<0.05), and FI was significantly negatively correlated with ox-LDL, 8-ISO and HSP-70 (P<0.05). The VI of the fetal brain in the pregnancy-induced hypertension group was significantly positively correlated with MDA, 8-iso, and HSP-70 in the umbilical cord blood of the patients (P<0.05), and VFI was significantly positively correlated with 8-iso and HSP-70.3D-CPA examination can find that the level of fetal placental blood flow parameters of pregnant women with pregnancy-induced hypertension is reduced, and the craniocerebral blood flow parameters are compensatedly increased, and it is related to intrauterine hypoxia. [ABSTRACT FROM AUTHOR]