Back to Search
Start Over
Palladium-catalyzed Hiyama cross-couplings of pyrimidin-2-yl tosylates with organosilanes.
- Source :
- Journal of Chemical Research; Jan/Feb2022, Vol. 46 Issue 1, p1-7, 7p
- Publication Year :
- 2022
-
Abstract
- An efficient palladium-catalyzed Hiyama reaction between various pyrimidin-2-yl tosylates with organosilanes has been developed. The use of CuCl with TBAF as additive is essential for promotion of the construction of the carbon–carbon bond. This procedure shows wide functional group tolerance for electrophilic pyrimidin-2-yl tosylates and has been extended to aromatic amino-substituted pyrimidin-2-yl tosylates, affording the desired C2-aryl and alkenyl pyrimidine derivatives in good to excellent yields. [ABSTRACT FROM AUTHOR]
- Subjects :
- CARBON-carbon bonds
PYRIMIDINE derivatives
FUNCTIONAL groups
PALLADIUM
ARYLATION
Subjects
Details
- Language :
- English
- ISSN :
- 17475198
- Volume :
- 46
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Journal of Chemical Research
- Publication Type :
- Academic Journal
- Accession number :
- 155828805
- Full Text :
- https://doi.org/10.1177/17475198211067163