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High SARS-CoV-2 Viral Load and Low CCL5 Expression Levels in the Upper Respiratory Tract Are Associated With COVID-19 Severity.
- Source :
- Journal of Infectious Diseases; 3/15/2022, Vol. 225 Issue 6, p977-982, 6p
- Publication Year :
- 2022
-
Abstract
- Mucosal immune response in the upper respiratory tract is crucial for initial control of viral replication, clearance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and progression of coronavirus disease 2019 (COVID-19). We analyzed SARS-CoV-2 RNA load and expression of selected immune genes in the upper respiratory tract (nasopharynx) of 255 SARS-CoV-2-infected patients and evaluated their association with severe COVID-19. SARS-CoV-2 replication in nasopharyngeal mucosa induces expression of several innate immune genes. High SARS-CoV-2 viral load and low CCL5 expression levels were associated with intensive care unit admission or death, although CCL5 was the best predictor of COVID-19 severity. [ABSTRACT FROM AUTHOR]
- Subjects :
- SARS-CoV-2
VIRAL load
COVID-19
Subjects
Details
- Language :
- English
- ISSN :
- 00221899
- Volume :
- 225
- Issue :
- 6
- Database :
- Complementary Index
- Journal :
- Journal of Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 155811730
- Full Text :
- https://doi.org/10.1093/infdis/jiab604