Effect of the polymeric matrix on the physicochemical properties of the Diclofenac sodium loaded fibers in Orodispersible Tablets.

The present study aimed to develop fibers of Diclofenac sodium (DS) by electrospinning technique and compressed into an orodispersible tablet by direct compression. The DS was compatible with the added excipients confirmed by the FTIR and DSC studies. There are no peaks of crystalline Diclofenac sodium visible in the XRD patterns of Diclofenac sodium loaded Eudragit L100 fibers which imply that the drug-loaded in the fibers was no longer present as crystalline, but fully converted into an amorphous state. The 1H NMR spectrum shows separate peaks for Diclofenac sodium and Eudragit L100 thereby indicating that there is intramolecular interaction between Diclofenac sodium and Eudragit L100, suggesting good compatibility. All formulations showed significant improvement in the rate of dissolution as compared to the crystalline active pharmaceutical ingredient. The results showed that the developed Diclofenac sodium loaded orodispersible tablet formulation was stable and can be potentially used in rheumatoid arthritis. [ABSTRACT FROM AUTHOR]